HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease

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dc.contributor.authorMahdi, Najat
dc.contributor.authorOla, Khadija Al
dc.contributor.authorSubaie, AbeerAbeer M Al
dc.contributor.authorAli, Muhallab E
dc.contributor.authorIrhayim, Zaid Al
dc.contributor.authorIrhayim, A Qader Al
dc.contributor.authorY Almawi, Wassim
dc.date.accessioned2022-04-12T05:55:44Z
dc.date.accessioned2023-08-19T08:55:58Z
dc.date.available2022-04-12T05:55:44Z
dc.date.available2023-08-19T08:55:58Z
dc.date.issued2008-04
dc.description.abstractWe investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.en_US
dc.identifier.citationMahdi, N., Al-Ola, K., Al-Subaie, A. M., Ali, M. E., Al-Irhayim, Z., Al-Irhayim, A. Q., & Almawi, W. Y. (2008). HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease. Clinical and Vaccine Immunology, 15(4), 729-731.en_US
dc.identifier.doihttps://doi.org/10.1128/CVI.00425-07
dc.identifier.urihttps://edms.wexl.in/handle/1/3204
dc.language.isoenen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.subjectHLAen_US
dc.subjectHaplotypesen_US
dc.subjectSickle Cell Anemiaen_US
dc.titleHLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell diseaseen_US
dc.title.alternativeClinical and Vaccine Immunologyen_US
dc.typeArticleen_US

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