HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease
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American Society for Microbiology
Abstract
We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.
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Mahdi, N., Al-Ola, K., Al-Subaie, A. M., Ali, M. E., Al-Irhayim, Z., Al-Irhayim, A. Q., & Almawi, W. Y. (2008). HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease. Clinical and Vaccine Immunology, 15(4), 729-731.