Modulation of Type 1 Diabetes Susceptibility by Tumor Necrosis Factor Alpha −308 G/A and Lymphotoxin Alpha +249 A/G Haplotypes and Lack of Linkage Disequilibrium with Predisposing DQB1-DRB1 Haplotypes in Bahraini Patients
| dc.contributor.author | Stayoussef, Mouna | |
| dc.contributor.author | Jenaidi, Fayza A Al | |
| dc.contributor.author | Abbasi, Abduljabbar Al | |
| dc.contributor.author | Khayyat, Khadija Al-Ola, Haya | |
| dc.contributor.author | Mahjoub, Touhami | |
| dc.contributor.author | Y Almawi, Wassim | |
| dc.date.accessioned | 2022-04-01T06:33:50Z | |
| dc.date.accessioned | 2023-08-19T08:55:54Z | |
| dc.date.available | 2022-04-01T06:33:50Z | |
| dc.date.available | 2023-08-19T08:55:54Z | |
| dc.date.issued | 2008-02 | |
| dc.description.abstract | necrosis factor alpha (TNF-α) −308 G/A and lymphotoxin alpha (LTα) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LTα +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-α/LTα alleles and susceptible/protective DRB1-DQB1 haplotypes. TNF-α/LTα T1DM-susceptible (−308G/+249G) and protective (−308G/+249A) haplotypes were identified. | en_US |
| dc.identifier.citation | Stayoussef, M., Al-Jenaidi, F. A., Al-Abbasi, A., Al-Ola, K., Khayyat, H., Mahjoub, T., & Almawi, W. Y. (2008). Modulation of type 1 diabetes susceptibility by tumor necrosis factor alpha− 308 G/A and lymphotoxin alpha+ 249 A/G haplotypes and lack of linkage disequilibrium with predisposing DQB1-DRB1 haplotypes in Bahraini patients. Clinical and Vaccine Immunology, 15(2), 379-381. | en_US |
| dc.identifier.doi | https://doi.org/10.1128/CVI.00410-07 | |
| dc.identifier.uri | https://edms.wexl.in/handle/1/3080 | |
| dc.language.iso | en | en_US |
| dc.publisher | American Society for Microbiology | en_US |
| dc.subject | Tumor | en_US |
| dc.subject | Lymphotoxin | en_US |
| dc.subject | Type 1 diabetes | en_US |
| dc.subject | T1DM | en_US |
| dc.subject | Autoimmune | en_US |
| dc.title | Modulation of Type 1 Diabetes Susceptibility by Tumor Necrosis Factor Alpha −308 G/A and Lymphotoxin Alpha +249 A/G Haplotypes and Lack of Linkage Disequilibrium with Predisposing DQB1-DRB1 Haplotypes in Bahraini Patients | en_US |
| dc.title.alternative | Clinical and Vaccine Immunology | en_US |
| dc.type | Article | en_US |
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