A common mutation in 5, 10‐methylenetetrahydrofolate reductase (MTHFR) gene in two Arab communities

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dc.date.accessioned2022-04-13T09:04:53Z
dc.date.accessioned2023-08-19T08:56:21Z
dc.date.available2022-04-13T09:04:53Z
dc.date.available2023-08-19T08:56:21Z
dc.date.issued2003-10
dc.description.abstractMethylenetetrahydrofolate reductase (MTHFR) plays a critical role in the B12-dependent methylation of homocysteine to methionine [1], and a reduction in its levels or activity leads to hyperhomocysteinemia [1], and is described as a risk for coronary artery disease (CAD) and deep vein thrombosis (DVT) [2]. The C677T mutation is a specific point mutation in the MTHFR gene which substitutes alanine for valine, and is associated with enzyme thermolability and reduced activity [3].en_US
dc.identifier.citationAl‐Habboubi, H., Tamim, H., Ameen, G., & Almawi, W. Y. (2003). A common mutation in 5, 10‐methylenetetrahydrofolate reductase (MTHFR) gene in two Arab communities. Journal of Thrombosis and Haemostasis, 1(10), 2246-2248.en_US
dc.identifier.doihttps://doi.org/10.1046/j.1538-7836.2003.00390.x
dc.identifier.urihttps://edms.wexl.in/handle/1/3226
dc.language.isoenen_US
dc.publisherBlackwell Science Incen_US
dc.subjectMutationsen_US
dc.subjectMethylenetetrahydrofolate reductaseen_US
dc.subjectHyperhomocysteinemiaen_US
dc.subjectGeneen_US
dc.subjectEnzymeen_US
dc.titleA common mutation in 5, 10‐methylenetetrahydrofolate reductase (MTHFR) gene in two Arab communitiesen_US
dc.title.alternativeJournal of Thrombosis and Haemostasisen_US
dc.typeArticleen_US

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