Loss of nuclear myosin 1 causes hemostatic defects and immune dysregulation
| dc.contributor.author | Venit, Tomas | |
| dc.contributor.author | Khalaji, Samira | |
| dc.contributor.author | Fambri, Valentina | |
| dc.contributor.author | Abdrobou, Wael | |
| dc.contributor.author | El Gindi, Mei | |
| dc.contributor.author | ETAL... | |
| dc.date.accessioned | 2026-07-10T13:52:04Z | |
| dc.date.available | 2026-07-10T13:52:04Z | |
| dc.date.issued | 2026-05-01 | |
| dc.description.abstract | The role of cellular metabolism in maintaining stem cell pluripotency and differentiation has been receiving more attention due to a direct link between metabolic state and the differentiation potential of cells. We showed previously that Nuclear myosin 1 (NM1) deletion leads to a metabolic switch from oxidative phosphorylation to aerobic glycolysis. Therefore, we asked if NM1 contributes to the cell differentiation of hematopoietic progenitor stem cells to terminal blood cells. By using NM1 wild-type (WT), knock-out (KO), and NM1-rescued (KO+NM1) mouse embryonic fibroblasts (MEF), as well as NM1 WT and KO mice, we found that NM1 deletion alters hematopoiesis-related metabolites and differentially regulates genes involved in platelet activation and immune response. Keywords Myosin I, Immune dysregulation, Cellular metabolism | |
| dc.identifier.citation | Venit, T., Khalaji, S., Fambri, V., Abdrobou, W., El Gindi, M., Shrestha, R., ... & Percipalle, P. (2020). Loss of nuclear myosin 1 causes hemostatic defects and immune dysregulation. Haematologica. | |
| dc.identifier.doi | https://doi.org/10.3324/haematol.2025.288392 | |
| dc.identifier.uri | https://repository.adu.ac.ae/handle/1/8370 | |
| dc.language.iso | en_US | |
| dc.publisher | Green | |
| dc.title | Loss of nuclear myosin 1 causes hemostatic defects and immune dysregulation | |
| dc.type | Article |