The impact of ncRNAs on type 2 diabetes: A comprehensive review covering molecular mechanisms to clinical applications

Abstract

Type 2 diabetes (T2D) is a complex metabolic disorder with rising global prevalence. This review examines the diverse roles of non-coding RNAs (ncRNAs) in T2D, focusing on their involvement in key biological processes such as insulin signaling, glucose metabolism, oxidative stress, and inflammation. We explore how ncRNAs interact with known T2D risk genes and contribute to epigenetic regulation associated with disease progression. Particular attention is given to the emerging potential of ncRNAs as biomarkers for early diagnosis and as targets for personalized therapeutic strategies. We also discuss current advances in modulating ncRNA expression, including findings from experimental models and clinical trials published between 1998 and 2025. Finally, the review considers how lifestyle factors and common comorbidities influence ncRNA expression, highlighting their wider implications in the context of T2D. Overall, the findings underscore the growing importance of ncRNAs in understanding, diagnosing, and treating T2D.

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