Association between renin–angiotensin–aldosterone system genotypes and haplotypes and risk of ischemic stroke of atherosclerotic etiology

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dc.contributor.authorSaidi, S
dc.contributor.authorMallat, SG
dc.contributor.authorY Almawi, Wassim
dc.contributor.authorMahjoub, T
dc.date.accessioned2022-03-02T09:16:37Z
dc.date.accessioned2023-08-19T08:55:48Z
dc.date.available2022-03-02T09:16:37Z
dc.date.available2023-08-19T08:55:48Z
dc.date.issued2009-06
dc.description.abstractAbstract Objective – The association of renin C-4063T and angiotensinogen (AGT) T174M, AGT M235T and AGT A-6G polymorphisms with ischemic stroke of atherosclerotic etiology was investigated in 329 Tunisian patients with stroke and 444 controls. Materials and methods – Genotyping was performed using PCR-RFLP and the contributions of polymorphisms to the risk of stroke were analyzed using haplotype and multivariate regression analysis. Results – AGT 235T and AGT-6G allele and AGT 235T/T, AGT-6A/G and AGT-6G/G genotype frequencies were higher in patients. Linkage disequilibrium (LD) was noted for AGT174T with AGT235M and AGT(-6)A in patients, while AGT235M was in LD with AGT(-6)A in controls and AGT235T was in LD with AGT(-6)G in both groups. The AGT 174T/235T/-6A and AGT 174T/235M/-6G haplotypes were positively and negatively associated with stroke respectively. Multivariate regression analysis identified AGT 174T/235M/-6A, AGT 174T/235T/-6G, AGT 174T/235T/-6A and AGT 174M/235T/-6A haplotypes to be significantly associated with an increased risk of stroke. Conclusions – Renin–angiotensin–aldosterone system polymorphisms influence the risk of atherosclerotic stroke in Tunisians.en_US
dc.identifier.citationSaidi, S., Mallat, S. G., Almawi, W. Y., & Mahjoub, T. (2009). Association between renin–angiotensin–aldosterone system genotypes and haplotypes and risk of ischemic stroke of atherosclerotic etiology. Acta neurologica scandinavica, 119(6), 356-363.en_US
dc.identifier.doihttps://doi.org/10.1111/j.1600-0404.2008.01105.x
dc.identifier.urihttps://edms.wexl.in/handle/1/2821
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.subjectGenotypesen_US
dc.subjectStrokeen_US
dc.subjectAngiotensinogenen_US
dc.subjectPolymorphismsen_US
dc.titleAssociation between renin–angiotensin–aldosterone system genotypes and haplotypes and risk of ischemic stroke of atherosclerotic etiologyen_US
dc.title.alternativeActa neurologica scandinavicaen_US
dc.typeArticleen_US

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