A regionally based precision medicine implementation initiative in North Africa:The PerMediNA consortium

dc.contributor.authorHamdi, Yosr
dc.contributor.authorBoujemaa, Maroua
dc.contributor.authorBen Aissa-Haj, Jihenne
dc.contributor.authorErrafii, Khaoula
dc.contributor.authorETAL..
dc.date.accessioned2025-10-13T05:31:38Z
dc.date.available2025-10-13T05:31:38Z
dc.date.issued2024-06
dc.descriptionThe past several decades has seen enormous progress in the field of genomic medicine [1]. Various efforts, including the Human Genome Project, deep catalogs of human genetic variations, along with the Genome Wide Association Studies (GWAS) revolution and massive sequencing have all resulted in a wealth of knowledge on the genetics of common diseases [[2], [3], [4], [5]]. This includes the discovery of more than 70,000 robust genetic associations to common diseases and traits, and important insights into the underlying basis of some rare diseases.
dc.description.abstractPrecision Medicine is being increasingly used in the developed world to improve health care. While several Precision Medicine (PM) initiatives have been launched worldwide, their implementations have proven to be more challenging particularly in low- and middle-income countries. To address this issue, the “Personalized Medicine in North Africa” initiative (PerMediNA) was launched in three North African countries namely Tunisia, Algeria and Morocco. PerMediNA is coordinated by Institut Pasteur de Tunis together with the French Ministry for Europe and Foreign Affairs, with the support of Institut Pasteur in France. The project is carried out along with Institut Pasteur d’Algérie and Institut Pasteur du Maroc in collaboration with national and international leading institutions in the field of PM including Institut Gustave Roussy in Paris. PerMediNA aims to assess the readiness level of PM implementation in North Africa, to strengthen PM infrastructure, to provide workforce training, to generate genomic data on North African populations, to implement cost effective, affordable and sustainable genetic testing for cancer patients and to inform policy makers on how to translate research knowledge into health products and services. Gender equity and involvement of young scientists in this implementation process are other key goals of the PerMediNA project. In this paper, we are describing PerMediNA as the first PM implementation initiative in North Africa. Such initiatives contribute significantly in shortening existing health disparities and inequities between developed and developing countries and accelerate access to innovative treatments for global health. Keywords Precision Medicine, Equity North Africa, Capacity Building, Affordable Genetic Testing
dc.identifier.citationHamdi, Y., Boujemaa, M., Aissa-Haj, J. B., Radouani, F., Khyatti, M., Mighri, N., ... & Abdelhak, S. (2024). A regionally based precision medicine implementation initiative in North Africa: The PerMediNA consortium. Translational Oncology, 44, 101940.
dc.identifier.doihttps://doi.org/10.1016/j.tranon.2024.101940
dc.identifier.urihttps://repository.adu.ac.ae/handle/1/7582
dc.language.isoen
dc.publisherElesevier
dc.titleA regionally based precision medicine implementation initiative in North Africa:The PerMediNA consortium
dc.typeArticle

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