Tamarix articulata Induced Prevention of Hepatotoxicity Effects of In Vivo Carbon Tetrachloride by Modulating Pro-Inflammatory Serum and Antioxidant Enzymes to Reverse the Liver Fibrosis
| dc.contributor.author | M Alnuqaydan, Abdullah | |
| dc.contributor.author | A. Alsahli, Mohammed | |
| dc.contributor.author | G Almutary,Abdulmajeed | |
| dc.contributor.author | ETAL.. | |
| dc.date.accessioned | 2024-11-15T06:39:21Z | |
| dc.date.available | 2024-11-15T06:39:21Z | |
| dc.date.issued | 2022-09-15 | |
| dc.description | The liver performs a key role in the regulation of numerous biochemical functions associated with metabolism [1]. Liver injury is a multi-factorial disease caused by environmental and chemical toxins, drugs, and alcohol intake, which induce oxidative stress, leading to complicated pathophysiology. Typically, the end result of this is cirrhosis and hepatocellular carcinoma (HCC) [2,3]. The liver is rich in mitochondria that aid in aerobic metabolism through the electron transport chain (ETC). During the process of oxidative phosphorylation, reactive oxygen species (ROS) are produced, and this means that hepatocytes are highly susceptible to oxidative stress, which ultimately leads to hepatocellular damage. Owing to a number of side effects of the existing therapeutic modalities used for liver diseases, the management of hepatocellular diseases is often poor. | |
| dc.description.abstract | This study evaluates the hepatoprotective activity of a Tamarix articulata extract against carbon tetrachloride-mediated hepatotoxicity in Wistar rats. Our results demonstrated that the oral administration of Tamarix articulata extract (50 mg/kg b.w.) significantly restored the serum levels of liver enzymes and antioxidant parameters (superoxide dismutase, catalase, glutathione reductase, and thiobarbituric reactive substances). Histopathology analysis revealed that Tamarix articulata extract significantly reduced hepatic fibrosis by inhibiting the necrosis of hepatocytes. Furthermore, serum pro-inflammatory (tumor necrosis factor-alpha, tumor growth factor-beta, and interleukin-6) markers were significantly restored. However, the anti-inflammatory cytokine adiponectin levels increased to normal levels in the group treated with Tamarix articulata extract. Additionally, we observed diminished reactive oxygen species production and the depolarization of mitochondrial membrane potential in hepatocytes extracted from animal livers treated with Tamarix articulata extract. Our findings suggest that Tamarix articulata extract prevents liver fibrosis induced by carbon tetrachloride and decreases the necrotic population of hepatocytes. These events restored the antioxidant enzymatic activity, serum levels of liver enzymes, and pro-inflammatory markers to their normal levels. Keywords: antioxidant; fibrosis; hepatotoxicity; inflammation; Tamarix articulata | |
| dc.identifier.citation | Alnuqaydan, A. M., Almutary, A. G., A. Alsahli, M., Alnasser, S., & Rah, B. (2022). Tamarix articulata induced prevention of hepatotoxicity effects of in vivo carbon tetrachloride by modulating pro-inflammatory serum and antioxidant enzymes to reverse the liver fibrosis. Antioxidants, 11(9), 1824. | |
| dc.identifier.doi | https://doi.org/10.3390/antiox11091824 | |
| dc.identifier.uri | https://repository.adu.ac.ae/handle/1/7036 | |
| dc.language.iso | en | |
| dc.publisher | MDPI | |
| dc.title | Tamarix articulata Induced Prevention of Hepatotoxicity Effects of In Vivo Carbon Tetrachloride by Modulating Pro-Inflammatory Serum and Antioxidant Enzymes to Reverse the Liver Fibrosis | |
| dc.type | Article |