The antiproliferative effect of glucocorticoids: is it related to induction of TGF-beta?

Abstract

Introduction expression of the immunosuppressive cytokine, trans-Glucocorticoids (GCs) are used in treating disordersforming growth factor (TGF)-b. Similar to GCs, TGF-of heightened immunity such as transplant rejection, b is a pleiotropic mediator that modulates several owing to their capacity to prevent T cell activation byaspects of the inflammatory response, and is a potent suppressor of T cell activation and cytokine expression.