Association of the IL‐10 Receptor A 536 G (S 138 G) Loss‐of‐Function Variant with Recurrent Miscarriage

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dc.contributor.authorMagdoud, Kalthoum
dc.contributor.authorHellal, Radhia
dc.contributor.authorZemni, Ramzi
dc.contributor.authorTouraine, Renaud
dc.contributor.authorMahjoub, Touhami
dc.contributor.authorY Almawi, Wassim
dc.date.accessioned2022-04-13T08:50:18Z
dc.date.accessioned2023-08-19T08:56:15Z
dc.date.available2022-04-13T08:50:18Z
dc.date.available2023-08-19T08:56:15Z
dc.date.issued2014-09
dc.description.abstractProblem We investigated the association of interleukin-10 receptor (IL10R1) loss-of-function variant A536G/S138G with recurrent pregnancy loss (RPL). Method of study Study subjects comprised 300 women with ≥3 miscarriages, and 350 control women. Results Significantly higher 536G-allele frequency was seen in RPL cases, thus assigning pathogenic role for this allele. Significant difference in A536G/S138G genotypes distribution was seen between RPL cases and controls, evidenced by enrichment of 536A/G and 536G/G genotypes in RPL cases. Setting A/A genotype as reference (OR = 1.00), increased RPL risk was seen with 536A/G, and more in 536G/G carriers, thereby establishing dose-dependency. Conclusion IL10R1 loss-of-function A536/S138G polymorphism may contribute to RPL pathogenesis.en_US
dc.identifier.citationMagdoud, K., Hellal, R., Zemni, R., Touraine, R., Mahjoub, T., & Almawi, W. Y. (2014). Association of the IL‐10 Receptor A 536 G (S 138 G) Loss‐of‐Function Variant with Recurrent Miscarriage. American journal of reproductive immunology, 72(1), 1-4.en_US
dc.identifier.doihttps://doi.org/10.1111/aji.12227
dc.identifier.urihttps://edms.wexl.in/handle/1/3224
dc.language.isoenen_US
dc.publisherJohn Wiley & Sonsen_US
dc.subjectRecurrent Miscarriageen_US
dc.subjectGenotypesen_US
dc.subjectRPL pathogenesisen_US
dc.subjectPolymorphismsen_US
dc.titleAssociation of the IL‐10 Receptor A 536 G (S 138 G) Loss‐of‐Function Variant with Recurrent Miscarriageen_US
dc.title.alternativeAmerican journal of reproductive immunologyen_US

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