Effects of 1H-1,2,3-Triazole Derivatives of 3-O-Acetyl-11-Keto-Beta-Boswellic Acid from Boswellia sacra Resin on T-Cell Proliferation and Activation
| dc.contributor.author | Meyiah, Abdo | |
| dc.contributor.author | Elkord, Eyad | |
| dc.contributor.author | Al-Harrasi, Ahmed | |
| dc.contributor.author | Avula, Satya Kumar | |
| dc.date.accessioned | 2025-09-09T05:06:15Z | |
| dc.date.available | 2025-09-09T05:06:15Z | |
| dc.date.issued | 2024 | |
| dc.description | Boswellia sacra resin (BSR) is a resin-producing tree that grows in South Oman (Dhofar region) [1], Yemen (Hadhramaut region), and northern Somalia [2]. BSR consists of various terpenes, which include mono- (C10), sesqui- (C15), di- (20), and tri-terpenes (C30). It is reported to possess antibacterial, anti-inflammatory, antidiabetic, and anticancer activities [3]. Boswellic acids (BAs) are natural products isolated from the resins of plants of the boswellia genus and are known for their medicinal potential [4]. The most popular BAs include β-boswellic acid (β-BA), 3-O-acetyl-β-boswellic acid (β-ABA), 11-keto-β-boswellic acid (β-KBA), and 3-O-acetyl-11-keto-β-boswellic acid (β-AKBA). Different BAs have shown promising therapeutic effects against various diseases such as inflammation-related disorders, including osteoarthritis, asthma, inflammatory bowel disease, and microbial infections, as well as Alzheimer’s disease [5,6,7,8,9,10]. In addition, BAs exhibit anticancer effects in a variety of tumors including breast, colorectal, lung, and gastric cancers [11,12,13,14]. | |
| dc.description.abstract | Background: 3-O-acetyl-11-keto-β-boswellic acid (β-AKBA), a triterpene natural product, is one of the main natural products of Boswellia sacra resin (BSR) and has reported biological and immunomodulatory effects. 1H-1,2,3-triazole derivatives of β-AKBA (named 6a–6d) were synthesized from β-AKBA. The 1H-1,2,3-triazole compounds are also known to have a wide range of biological and pharmacological properties as demonstrated by in vitro and in vivo studies. This study aimed to investigate the effects of these 1H-1,2,3-triazole derivatives of β-AKBA on human T-cell proliferation and activation. Methods: PBMCs isolated from healthy donors were activated by anti-CD3/CD28 monoclonal antibodies in the presence of β-AKBA (1) or 1H-1,2,3-triazole derivatives of β-AKBA or DMSO controls. Results: We found that similar to the parent compound β-AKBA (1), derivatives 6a, 6b, and 6d significantly inhibited T-cell expansion/proliferation and reduced the levels of CD25 activation marker on CD4+ and CD8+ T cells without exerting significant cytotoxic effects on T-cell viability at a concentration of 25 µM. However, compound 6c further inhibited T-cell expansion/proliferation and CD25 expression, but had a significant cytotoxic effect on cell viability at similar concentrations of 25 µM. Conclusions: These findings demonstrate the immunoinhibitory effects of β-AKBA (1) and its corresponding triazole derivatives on T-cell proliferation and activation, highlighting the promising therapeutic potential of these compounds in T-cell-mediated diseases. Keywords: boswellic acid, T cells, CD25, β-AKBA, 1H-1,2,3-triazole | |
| dc.identifier.citation | Meyiah, A., Avula, S. K., Al-Harrasi, A., & Elkord, E. (2024). Effects of 1 H-1, 2, 3-Triazole Derivatives of 3-O-Acetyl-11-Keto-Beta-Boswellic Acid from Boswellia sacra Resin on T-Cell Proliferation and Activation. Pharmaceuticals, 17(12), 1650. | |
| dc.identifier.doi | https://doi.org/10.3390/ph17121650 | |
| dc.identifier.uri | https://repository.adu.ac.ae/handle/1/7398 | |
| dc.language.iso | en | |
| dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | |
| dc.title | Effects of 1H-1,2,3-Triazole Derivatives of 3-O-Acetyl-11-Keto-Beta-Boswellic Acid from Boswellia sacra Resin on T-Cell Proliferation and Activation | |
| dc.type | Article |