Targeting LIN28: a new hope in prostate cancer theranostics

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dc.contributor.authorAlmutary, Abdulmajeed
dc.contributor.authorCharbe, Nitin
dc.contributor.authorAlnuqaydan, Abdullah
dc.date.accessioned2024-11-11T08:51:36Z
dc.date.available2024-11-11T08:51:36Z
dc.date.issued2021-10-01
dc.descriptionProstate cancer (PCa) is one of the leading causes of cancer deaths in men worldwide [Citation1,Citation2], claiming over 350,000 lives annually [Citation3]. Global cancer statistics for 2018 show that PCa is still the second-most frequent malignant cancer globally and there are estimated to be 2,293,818 new cases by 2040 [Citation4]. Compared with many other cancer types, prostate cancer grows notoriously slowly, with a low cancer mortality rate [Citation5]. When the cancer is localized within a specific organ, it is considered potentially curable but, sadly, cancer patients who develop castration-resistant cancers (CRPC) have a significantly decreased life expectancy
dc.description.abstractThe mortality and morbidity rates for prostate cancer have recently increased to alarming levels, rising higher than lung cancer. Due to a lack of drug targets and molecular probes, existing theranostic techniques are limited. Human LIN28A and its paralog LIN28B overexpression are associated with a number of tumors resulting in a remarkable increase in cancer aggression and poor prognoses. The current review aims to highlight recent work identifying the key roles of LIN28A and LIN28B in prostate cancer, and to instigate further preclinical and clinical research in this important area. Keywords: biomarker, LIN28A, LIN28B, prostate cancer, theranostic
dc.identifier.citationShrivastava, G., Aljabali, A. A., Shahcheraghi, S. H., Lotfi, M., Shastri, M. D., Shukla, S. D., ... & Tambuwala, M. M. (2021). Targeting LIN28: a new hope in prostate cancer theranostics. Future Oncology, 17(29), 3873-3880.
dc.identifier.doihttps://doi.org/10.2217/fon-2021-0247
dc.identifier.urihttps://repository.adu.ac.ae/handle/1/6967
dc.language.isoen
dc.publisherTaylor & Francis
dc.titleTargeting LIN28: a new hope in prostate cancer theranostics
dc.typeArticle

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