Impact of aspartame and sucralose consumption on blood glucose homeostasis and haemoglobin level in male albino rats

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dc.contributor.authorKhamis, NA
dc.contributor.authorTayel, DI
dc.contributor.authorAborhyem, SM
dc.date.accessioned2025-10-24T05:41:16Z
dc.date.available2025-10-24T05:41:16Z
dc.date.issued2020
dc.description.abstractMethods: 54 male albino rats were divided into five groups, twelve rats in each group except control group 6 rats. Sweetal 2 and 4 g/kg and sugar match 0.8 and 1.6 g/kg were given orally every day for 12 weeks, artificial sweeteners were omitted for further 6 weeks. Rats were euthanized and FBG, fasting insulin, HOMA-IR, HbAIC and CBC were measured. Results: HOMA-IR increased in rats supplemented by high doses of either sweetener, HbA1c significant increased with low and high doses of Sweetal 6.43 and 6.85 respectively. Haemoglobin level decreased with low dose aspartame by 1.0%. Terminating sweeteners intake resulted in a decline in blood glucose homeostasis and also affected haematocrit parameters. Conclusion: Sucralose and aspartame intake had a significant impact on blood glucose homeostasis and hemoglobin levels in male albino rats. Keywords Blood glucose, Aspartame, Sucralose, Impact
dc.identifier.citationKhamis, N. A., Tayel, D. I., & Aborhyem, S. M. (2020). Impact of aspartame and sucralose consumption on blood glucose homeostasis and haemoglobin level in male albino rats. Clinical Nutrition ESPEN, 40, 592.
dc.identifier.doihttps://doi.org/10.1016/j.clnesp.2020.09.556
dc.identifier.urihttps://repository.adu.ac.ae/handle/1/7617
dc.language.isoen_US
dc.publisherElsevier
dc.titleImpact of aspartame and sucralose consumption on blood glucose homeostasis and haemoglobin level in male albino rats
dc.typeArticle

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