The Viral Capsid As Novel Nanomaterials for Drug Delivery

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dc.contributor.authorAlmutary,Abdulmajeed
dc.contributor.authorAljabali, Alaa
dc.contributor.authorAlnuqaydan, Abdullah
dc.contributor.authorETAL..
dc.date.accessioned2024-11-08T10:47:33Z
dc.date.available2024-11-08T10:47:33Z
dc.date.issued2021-10
dc.descriptionViruses are obligate intracellular parasites. When a susceptible and permissive cell becomes infected with a particular virus, the cell cycle is redirected to produce additional viruses. All viral organisms have genetic material in either RNA or DNA format [Citation1]. The genomic nucleic acid may be either single-stranded or double-stranded, circular or linear and either positive or negative in polarity. A virion is a complete component of the virus made up of nucleic acid and an outer protein layer that shields the nucleic acid inside. The amount of RNA or DNA present within a simple virus is sufficient to encode a few genes to generate viral proteins.
dc.description.abstractThe purpose of this review is to highlight recent scientific developments and provide an overview of virus self-assembly and viral particle dynamics. Viruses are organized supramolecular structures with distinct yet related features and functions. Plant viruses are extensively used in biotechnology, and virus-like particulate matter is generated by genetic modification. Both provide a material-based means for selective distribution and delivery of drug molecules. Through surface engineering of their capsids, virus-derived nanomaterials facilitate various potential applications for selective drug delivery. Viruses have significant implications in chemotherapy, gene transfer, vaccine production, immunotherapy and molecular imaging. The purpose of this review is to highlight recent scientific developments and provide an overview of virus self-assembly and viral particle dynamics. Viruses are organized supramolecular structures with distinct yet related features and functions. Plant viruses are extensively used in biotechnology, and virus-like particulate matter is generated by genetic modification. Both provide a material-based means for selective distribution and delivery of drug molecules. Through surface engineering of their capsids, virus-derived nanomaterials facilitate various potential applications for selective drug delivery. Viruses have significant implications in chemotherapy, gene transfer, vaccine production, immunotherapy and molecular imaging. Here we performed a comprehensive database search to review findings in this area, demonstrating that viral nanostructures possess unique properties that make them ideal for applications in diagnostics, cell labeling, contrasting agents and drug delivery structures. Keywords: nanomaterials, nanomedicine, therapeutics delivery, viral nanotechnology, viruses
dc.identifier.citationAljabali, A. A., Hassan, S. S., Pabari, R. M., Shahcheraghi, S. H., Mishra, V., Charbe, N. B., ... & Tambuwala, M. M. (2021). The viral capsid as novel nanomaterials for drug delivery. Future science OA, 7(9), FSO744.
dc.identifier.doihttps://doi.org/10.2144/fsoa-2021-0031
dc.identifier.urihttps://repository.adu.ac.ae/handle/1/6955
dc.language.isoen
dc.publisherTaylor and francis
dc.titleThe Viral Capsid As Novel Nanomaterials for Drug Delivery
dc.typeReview

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