Temporal trends in transfusion-transmissible infections among blood donors in Jordan: A large-scale Amman-based surveillance update (2018-2019)

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dc.contributor.authorAtoom, Ali
dc.contributor.authorAl-Abadi, Baheieh
dc.contributor.authorAl-Hiary, Mansour
dc.contributor.authorAlzubi, Bayan
dc.contributor.authorAl-Saeidat, Sanaa
dc.contributor.authorAl-Qaisi, Talal
dc.date.accessioned2026-01-19T07:52:44Z
dc.date.available2026-01-19T07:52:44Z
dc.date.issued2025-11-21
dc.descriptionBlood transfusion remains a critical, life-saving medical intervention, but it carries the risk of transmitting blood-borne pathogens collectively referred to as transfusion-transmitted infections (TTIs). These infections include hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and Treponema pallidum.[1] To ensure the safety of blood supplies, the World Health Organization (WHO) recommends universal screening of donated blood using sensitive and specific assays.[2] Despite these efforts, disparities persist: although high-income countries collect around 40% of global blood donations, they account for only 16% of the world’s population. In contrast, low- and middle-income countries, including many in the Eastern Mediterranean region, rely heavily on transfusions for vulnerable populations such as children under 5, with 54% of transfusions going to this age group.
dc.description.abstractTransfusion-transmissible infections (TTIs) remain a global concern in blood safety. This study presents the largest Amman-based dataset on Royal Medical Services donors since 2016 (n = 49,296 donations) and the first to apply a monthly Chi-square (χ2) trend analysis for TTI surveillance in Jordan. Blood donations collected between July 2018 and December 2019 were screened for hepatitis B surface antigen (HBsAg), hepatitis B core antibody (HBcAb), hepatitis C virus antibody (HCV Ab), human immunodeficiency virus (HIV) 1/2 antibodies, and Treponema pallidum using electrochemiluminescence assays, followed by confirmatory enzyme-linked immunosorbent assay tests. HBcAb was detected in 3.44% of donors, HBsAg in 0.41%, and HCV Ab in 0.10%. No confirmed cases of HIV or syphilis were found. These rates are lower than previously reported national estimates, suggesting a continued decline in hepatitis B virus and hepatitis C virus (HCV) prevalence. Chi-square tests revealed significant monthly variation for HBcAb (P < .001) and HBsAg (P < .001), while HCV trends were not significant. The majority of donors were male (98.2%) and from Amman (98.24%), limiting national generalizability. Although the dataset predates the COVID-19 pandemic and is geographically constrained, it remains the most recent and comprehensive post-2016 dataset available for national TTI surveillance. This study highlights low national TTI prevalence and underscores the value of blood donor screening as a tool for public health surveillance, especially in refugee-hosting contexts. The application of temporal analysis enhances its relevance for infection monitoring and health policy. Findings support the integration of seasonal trend surveillance into Jordan’s national blood safety strategy and align with global goals to eliminate communicable diseases by 2030. Keywords Blood Donors, Blood Safety, Hepatitis B, Hepatitis C, HIV Infections, Transfusion-Transmitted Infection
dc.identifier.citationAtoom, A., Al-Abadi, B., Al-Hiary, M., Alzubi, B., Al-Saeidat, S., & Al-Qaisi, T. (2025). Temporal trends in transfusion-transmissible infections among blood donors in Jordan: A large-scale Amman-based surveillance update (2018–2019). Medicine, 104(47), e45847.
dc.identifier.doi10.1097/MD.0000000000045847
dc.identifier.urihttps://repository.adu.ac.ae/handle/1/8021
dc.language.isoen
dc.publisherWolters Kluwer Health
dc.titleTemporal trends in transfusion-transmissible infections among blood donors in Jordan: A large-scale Amman-based surveillance update (2018-2019)
dc.typeArticle

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