Non-coding RNAs as Key Regulators of the Notch Signaling Pathway in Glioblastoma: Diagnostic, Prognostic, and Therapeutic Targets
| dc.contributor.author | G Almutary, Abdulmajeed | |
| dc.contributor.author | Mishra, Vijay | |
| dc.contributor.author | Serrano-Aroca, Ángel | |
| dc.contributor.author | ETAL.. | |
| dc.date.accessioned | 2024-11-15T05:50:48Z | |
| dc.date.available | 2024-11-15T05:50:48Z | |
| dc.date.issued | 2023-07-24 | |
| dc.description | Glioma is the most prevalent and aggressive tumor of the central nervous system. According to cellular sources, gliomas may be divided into oligodendroglioma, astrocytoma, mixed gliomas (oligo-astrocytomas), and ependymomas [1]. The World Health Organization (WHO) has separated gliomas into four grade subtypes. Grades I and II are classically investigated as low-grade gliomas, whereas grade III and IV tumor types are perceived as high-grade glioma types. Glioblastoma multiform (GBM, grade IV astrocytoma) is a competitive and fast-growing tumor, with an average survival time of 12-14 months after preliminary diagnosis [2]. Thus the discovery of an impressive therapeutic approach is essential in this disease [2]. | |
| dc.description.abstract | Glioblastoma multiforme (GBM) is a highly invasive brain malignancy originating from astrocytes, accounting for approximately 30% of central nervous system malignancies. Despite advancements in therapeutic strategies including surgery, chemotherapy, and radiopharmaceutical drugs, the prognosis for GBM patients remains dismal. The aggressive nature of GBM necessitates the identification of molecular targets and the exploration of effective treatments to inhibit its proliferation. The Notch signaling pathway, which plays a critical role in cellular homeostasis, becomes deregulated in GBM, leading to increased expression of pathway target genes such as MYC, Hes1, and Hey1, thereby promoting cellular proliferation and differentiation. Recent research has highlighted the regulatory role of non-coding RNAs (ncRNAs) in modulating Notch signaling by targeting critical mRNA expression at the post-transcriptional or transcriptional levels. Specifically, various types of ncRNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been shown to control multiple target genes and significantly contribute to the carcinogenesis of GBM. Furthermore, these ncRNAs hold promise as prognostic and predictive markers for GBM. This review aims to summarize the latest studies investigating the regulatory effects of ncRNAs on the Notch signaling pathway in GBM. Keywords: Glioblastoma, Notch signaling, lncRNAs, miRNAs | |
| dc.identifier.citation | Shahcheraghi, S. H., Asl, E. R., Lotfi, M., Ayatollahi, J., Khaleghinejad, S. H., Aljabali, A. A., ... & Tambuwala, M. M. (2023). Non-coding RNAs as Key Regulators of the Notch Signaling Pathway in Glioblastoma: Diagnostic, Prognostic, and Therapeutic Targets. | |
| dc.identifier.doi | https://doi.org/10.20944/preprints202307.1595.v1 | |
| dc.identifier.uri | https://repository.adu.ac.ae/handle/1/7034 | |
| dc.language.iso | en | |
| dc.publisher | Preprints | |
| dc.title | Non-coding RNAs as Key Regulators of the Notch Signaling Pathway in Glioblastoma: Diagnostic, Prognostic, and Therapeutic Targets | |
| dc.type | Other |