A deep learning model to enhance lung cancer detection using ‘Dual-Branch’ model classification approach
| dc.contributor.author | Murad Al-Rajab | |
| dc.contributor.author | Emad Shweikeh | |
| dc.contributor.author | Abderahman Ahmed | |
| dc.contributor.author | ETAL.. | |
| dc.date.accessioned | 2026-02-09T10:52:22Z | |
| dc.date.available | 2026-02-09T10:52:22Z | |
| dc.date.issued | 2026 | |
| dc.description | Lung cancer is one of the leading causes of cancer-related deaths globally, with an estimated 1.8 million fatalities annually [1]. Despite advancements in diagnostic and therapeutic techniques, the prognosis for lung cancer remains poor, with only a 19% five-year survival rate [2]. Smoking is a major risk factor, contributing to approximately 85% of cases. Other contributing factors include genetic predispositions and environmental pollutants. Recent studies emphasize the importance of early detection, which significantly improves survival rates, quality of life, and reduces treatment costs (Pinsky & Berg, 2020). For example, survival rates can increase from 5% to 55% with early detection [3]. The integration of machine learning (ML) in medical imaging presents a promising avenue for enhancing early detection and classification of lung cancer. However, challenges persist, such as the limited availability of large, high-quality datasets, difficulty in selecting and validating the most effective ML models, and the high computational costs associated with these technologies [4]. Addressing these gaps is crucial to improving diagnostic accuracy and ultimately improving patient. | |
| dc.description.abstract | Cancer remains a life-threatening global challenge, with lung cancer ranking among the most devastating forms, impacting millions annually. Early detection and accurate classification are essential for improving patient survival rates, and computed tomography (CT) has become a critical tool in lung cancer diagnosis. Despite advancements, previous studies have faced notable challenges, particularly a shortage of available samples and limitations in input modalities, both of which hinder model performance. Addressing these issues, this research introduces the Dual-Branch Model Classification Approach (DbMCA), a two-stage strategy that integrates image and mask data to enhance detection accuracy and scalability. Two comparative experiments were conducted using the LIDC-IDRI dataset with varying data sizes to evaluate the impact of sample size and dual-input modalities. The DbMCA achieved remarkable results, as it performed higher accuracy results a 91.21% accuracy and 91.18% F1-score in the smaller dataset and an exceptional 98.04% accuracy and 98.01% F1-score in the larger dataset. CNN performance on sparse mask data declines with scale, while DNN and SVM consistently outperform it, highlighting architecture sensitivity to sparsity. This demonstrates the model’s improved discriminative power and potential for detecting subtle lung cancer patterns, however, based on statistical evidence DbMCA significantly outperforms weaker baselines and successfully integrates multi-modal information. Nonetheless, certain limitations were observed, such as the high computational requirements stemming from large sample sizes, the constrained information provided by segmentation masks, and the presence of potential biases in the dataset. These challenges hinder the model’s ability to generalize effectively. Future research should aim to enhance image quality, broaden the scope of datasets, and overcome segmentation-related constraints to make further progress in lung cancer detection. The DbMCA represents a significant step forward in improving the performance and scalability of diagnostic tools, offering the potential for more effective and lifesaving interventions in lung cancer care. Keywords: Lung Cancer Detection, Computed Tomography (CT), Dual-Branch Model, Multi-Modal Learning, Image and Mask Integration, Deep Learning, Convolutional Neural Networks (CNN), Support Vector Machine (SVM), Deep Neural Networks (DNN), LIDC-IDRI Dataset, Medical Image Classification, Early Cancer Diagnosis, Model Scalability. | |
| dc.identifier.citation | Shweikeh, E., Al-Rajab, M., Lu, J., Xu, Q., Joy, M., Ahmed, A., & Chang, H. (2026). A deep learning model to enhance lung cancer detection using ‘Dual-Branch’model classification approach. PloS one, 21(1), e0339404. | |
| dc.identifier.doi | https://doi.org/10.1371/journal.pone.0339404 | |
| dc.identifier.uri | https://repository.adu.ac.ae/handle/1/8183 | |
| dc.language.iso | en | |
| dc.publisher | Public Library of Science | |
| dc.title | A deep learning model to enhance lung cancer detection using ‘Dual-Branch’ model classification approach | |
| dc.type | Article |
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