Clinical immunology Single nucleotide polymorphism of transforming growth factor-β1 and interleukin-6 as risk factors for ovarian cancer

Abstract

varian cancer (OC) is one of the most common cancers in women worldwide, and a leading cause of death among gynecological malignancies [1]. The incidence of OC among Tunisian women was approximately 4/100,000, with an estimated 93 new cases diagnosed annually [2]. The pathogenesis of OC is not well characterized. In fact, most patients at diagnosis present with advanced stage of disease, and its treatment is refractory to chemotherapy and surgery [3]. The lack of available sensitive and specific screening tests, along with the identification of predictive and prognostic factors, contributes to the aggravation of OC [4, 5]