The NEIGHBOR Consortium Primary Open-Angle glaucoma genome-wide association study: Rationale, study design, and clinical variables
| dc.contributor.author | Wiggs, Janey L. | |
| dc.contributor.author | Hauser, Michael A. | |
| dc.contributor.author | Abdrabou, Wael | |
| dc.contributor.author | ETAL.. | |
| dc.date.accessioned | 2024-10-30T08:23:04Z | |
| dc.date.available | 2024-10-30T08:23:04Z | |
| dc.date.issued | 2013-09 | |
| dc.description | Primary open-angle glaucoma (POAG) is the most common glaucoma subtype in the Western world. Among people older than 70 years, the prevalence of POAG is 6% in white populations, 16% in black populations and 3% in Asians | |
| dc.description.abstract | Primary open-angle glaucoma (POAG) is a common disease with complex inheritance. The identification of genes predisposing to POAG is an important step toward the development of novel gene-based methods of diagnosis and treatment. Genome-wide association studies (GWAS) have successfully identified genes contributing to complex traits such as POAG however, such studies frequently require very large sample sizes, and thus, collaborations and consortia have been of critical importance for the GWAS approach. In this report we describe the formation of the NEIGHBOR consortium, the harmonized case control definitions used for a POAG GWAS, the clinical features of the cases and controls and the rationale for the GWAS study design. Keywords: Genetics, Genome-Wide Association Study, Primary Open-Angle Glaucoma | |
| dc.identifier.citation | Liu, Y., Rozsa, F. W., Schuman, J. S., & Zack, D. (2013). The NEIGHBOR Consortium Primary Open Angle Glaucoma Genome-wide Association Study: Rationale, study design... J Glaucoma, 22(7), 517-525. | |
| dc.identifier.doi | https://doi.org/10.1097/IJG.0b013e31824d4fd8 | |
| dc.identifier.uri | https://repository.adu.ac.ae/handle/1/6893 | |
| dc.language.iso | en | |
| dc.publisher | Lippincott, Williams & Wilkins (LWW) | |
| dc.title | The NEIGHBOR Consortium Primary Open-Angle glaucoma genome-wide association study: Rationale, study design, and clinical variables | |
| dc.type | Article |