Biomarkers for Kidney-Transplant Rejection: A Short Review Study
| dc.contributor.author | Sharaby ,Israa | |
| dc.contributor.author | Alksas , Ahmed | |
| dc.contributor.author | El-Ghar, Mohamed Abou | |
| dc.contributor.author | Eldeeb, Mona | |
| dc.contributor.author | Ghazal , Mohammed | |
| dc.contributor.author | Gondim, Dibson | |
| dc.contributor.author | El-Baz , Ayman | |
| dc.date.accessioned | 2024-02-02T06:41:57Z | |
| dc.date.available | 2024-02-02T06:41:57Z | |
| dc.date.issued | 2023-08 | |
| dc.description | Kidney transplantation is a superior treatment to dialysis for individuals with chronic kidney disease or end-stage renal failure, boasting up to 97% survival rates for transplanted kidneys within one year [1]. Nevertheless, a significant hurdle is the limited availability of donors, mainly due to the risk of immune rejection. When genetically dissimilar donor tissue is transplanted, the recipient’s immune system may perceive it as foreign, leading to potential graft rejection [2]. | |
| dc.description.abstract | Kidney transplantation is the preferred treatment for end-stage renal failure, but the limited availability of donors and the risk of immune rejection pose significant challenges. Early detection of acute renal rejection is a critical step to increasing the lifespan of the transplanted kidney. Investigating the clinical, genetic, and histopathological markers correlated to acute renal rejection, as well as finding noninvasive markers for early detection, is urgently needed. It is also crucial to identify which markers are associated with different types of acute renal rejection to manage treatment effectively. This short review summarizes recent studies that investigated various markers, including genomics, histopathology, and clinical markers, to differentiate between different types of acute kidney rejection. Our review identifies the markers that can aid in the early detection of acute renal rejection, potentially leading to better treatment and prognosis for renal-transplant patients. Keywords: Acute-mediated rejection (AMR); biomarkers; histopathological markers; kidney-transplant rejection; renal rejection | |
| dc.identifier.citation | Sharaby, I., Alksas, A., Abou El-Ghar, M., Eldeeb, M., Ghazal, M., Gondim, D., & El-Baz, A. (2023). Biomarkers for Kidney-Transplant Rejection: A Short Review Study. Biomedicines, 11(9), 2437. | |
| dc.identifier.doi | https://doi.org/10.3390/biomedicines11092437 | |
| dc.identifier.uri | https://dspace.adu.ac.ae/handle/1/769 | |
| dc.language.iso | en | |
| dc.publisher | MDPI | |
| dc.title | Biomarkers for Kidney-Transplant Rejection: A Short Review Study | |
| dc.type | Article |